Isomorphic Labs, Interface Design, Open Relating Agents cover

Isomorphic Labs, Interface Design, Open Relating Agents

MAY 20, 2026 · 2h 10m
WATCH

Cerebras IPO'd on the NASDAQ and popped 160 percent before settling at 100. Compute futures are showing up on the Chicago Mercantile Exchange, right next to corn and grain — which means somebody's pricing in a compute crunch within two to three years. Demis Hassabis's Isomorphic Labs raised $2.1B to solve all disease. Musk's case against OpenAI got thrown out on a timing technicality. OpenAI bought a four-letter podcast for around a hundred million that neither host could quite pull from memory. Siri's opening up to outside models — called it OPEN RELATIONSHIPS.

Then there's the burger joint. Tay walks into an empty place in a small Portuguese town called Buns. The owner — disheveled, wired, looks like he hasn't showered in days — pulls out his laptop and shows off a full localhost ops suite he's built for his restaurant. Sales dashboards. Accounting. A cinematic universe of AI-generated cartoons featuring skateboarding bananas speaking the regional dialect. A Telegram-controlled QR-code two-player game on the wall. The feature he uses most? Photographing supplier invoices to send to his accountant — same job he used to do with paper.

Also: Claude Opus 4.7 has started pushing back instead of agreeing. Meta's Tribe V2 models what's happening in your brain when you use a product. OpenHuman trends on GitHub. The Hours voice agent monologued for thirty seconds and hung up on River and Nonno mid-call. Land Library hits its first real product-market-fit moment — a thirty-year real estate veteran asking how to get more access. The deep dive goes into interfaces: tables, beds, the Hong Kong rooftop cinema that turned Dirty Dancing into a participatory event, holographic wearables, ingestibles, the jacket that vibrates left to turn you.

If we stop measuring AI by GDP and start measuring hours saved, dopamine spent, and addiction risk — what does the real ROI dashboard actually look like?TIMESTAMPS

(00:00) Cold open

(02:51) Weekly Check-in

(03:39) News

(28:26) Tools

(44:23) Building

(56:47) Rabbit Holes

(01:03:34) Open Questions

(01:17:23) Deep Dive — Interfaces

(01:47:52) AMA

RESOURCES

PEOPLE

Demis Hassabis — Google DeepMind co-founder, runs Isomorphic Labs

Johnny Ive — collaborating with OpenAI on a hardware project

Spike Jonze — directed "Her"

Stefan Sagmeister — designer, recent Long Now talk on progress

PROJECTS / COMPANIES / TOOLS

Cerebras Systems — AI chips, IPO'd with 160% pop on NASDAQ

Claude Opus 4.7 — Anthropic's model, now pushing back instead of agreeing

Gemini Flash Live 3.1 — Google voice model powering Hours

Hours — their voice-based micro-consulting agent

Isomorphic Labs — Hassabis's $2.1B drug-discovery raise

Land Library / Landbook — their land-relationship tool

OpenHuman — Mac-native open source agent, trending on GitHub

TBPN — podcast OpenAI acquired for ~$100M [exact letters unclear — check ~9:42]

Tribe V2 — Meta's brain-response modeling tool

FRAMEWORKS / CONCEPTS / LAWS

Bullshit Jobs — ~60% of white-collar work is unnecessary, per the book

Compute futures — arriving on the Chicago Mercantile Exchange

Gross National Happiness — Bhutan's alternative to GDP

Kaitiaki — Māori concept of land stewardship

Treaty of Waitangi — Māori–British translation gap on land ownership

PAPERS / ARTICLES / ESSAYS

Solve Everything — paper by Alex Grosnauis and Peter de Montes [names unclear — check ~16:36]

OTHER

Buns — Portuguese burger joint with a full localhost ops suite and AI banana cartoons